From 1982, the Tertiary Sisters of Saint Francis of Assisi established the Saint Joseph Children and Adult Home (SAJOCAH) resource unit in Bafut, followed by the Integrated School for the Blind in Kumbo by the CBC in 1984. These institutions pioneered braille literacy, vocational training, mobility orientation, and inclusive education in the region, operating initially under the medical model of disability but progressively transitioning toward a social inclusion paradigm. The empowerment activities of the CBC and Catholic missions spanned education, healthcare, economic and vocational training, social advocacy, sports and cultural integration, and digital empowerment, collectively dismantled structural barriers that had historically excluded PWVIs from societal participation. The implications of these activities included the entry of PWVIs into formal employment as teachers, lecturers, journalists, social workers, and counselors; their self-employment through cane weaving, beadwork, and petty trade; and their increasing participation in education from primary to university level. However, limited funding, inadequate institutional capacity, the multiplicity and mismanagement of empowerment organizations, and deep-seated cultural beliefs and stigma constituted persistent challenges that constrained the pace and depth of full inclusion. The study therefore submits that, despite the prevailing limitations, faith-based organizations most especially the CBC and Catholic Church missions served as the primary architects of socio-economic inclusion for Persons With Visual Impairment in the North West Region of Cameroon.